Related Experiment Videos
Regional correlation by color-coded tissue Doppler to quantify improvements in mechanical left ventricular synchrony
Hideaki Kanzaki1, Didier Jacques, L Elif Sade
1Cardiovascular Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA.
Insights
Cardiac resynchronization therapy (CRT) improves heart function in heart failure patients with left bundle branch block. A new mitral annular velocity index shows significant improvement after CRT.
Area of Science:
- Cardiology
- Medical Imaging
- Biomedical Engineering
Background:
- Heart failure (HF) with left bundle branch block (LBBB) is associated with impaired cardiac synchrony.
- Cardiac resynchronization therapy (CRT) is a treatment option for selected HF patients.
- Assessing cardiac synchrony is crucial for optimizing CRT response.
Purpose of the Study:
- To evaluate a novel synchrony index derived from mitral annular velocity (MAV) using color tissue Doppler.
- To assess the effectiveness of this index in patients undergoing CRT.
Main Methods:
- A study involving 19 subjects: 9 patients with HF and LBBB, and 10 healthy controls.
- MAV-derived synchrony index measured at baseline, and 1, 3, and 6 months post-CRT in patients.
- Comparison of synchrony index between HF patients and controls, and changes over time after CRT.
Main Results:
- Baseline synchrony index was significantly lower in HF patients with LBBB compared to controls (r = 0.60 ± 0.13 vs 0.94 ± 0.02; p < 0.01).
- The synchrony index in HF patients improved significantly at 6 months after CRT (r = 0.77 ± 0.09; p < 0.05 vs baseline).
Conclusions:
- The MAV-derived synchrony index effectively differentiates cardiac synchrony between healthy individuals and HF patients with LBBB.
- This index shows significant improvement following CRT, indicating its potential as a tool to monitor treatment response.
Abstract:
Cardiac resynchronization therapy (CRT) can improve cardiac function in patients with heart failure and left bundle branch block. To test a new synchrony index derived from mitral annular velocity by color tissue Doppler, 19 subjects were studied: 9 patients with heart failure and left bundle branch block at baseline and at 1, 3 and 6 months after CRT and 10 normal controls. The synchrony index in patients with heart failure was less than that in controls at baseline (r = 0.60 +/- 0.13 vs 0.94 +/- 0.02; p <0.01), but improved at 6 months after CRT (r = 0.77 +/- 0.09; p <0.05 vs baseline).