Related Experiment Videos
Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization
M L Bruschi1, M L C Cardoso, M B Lucchesi
1Departamento de Farmácia e Farmacologia, Universidade Estadual de Maringá, Av. Colombo 5790, CEP 87020-900, Maringá, PR, Brazil.
International Journal of Pharmaceutics
|September 16, 2003
Summary
Gelatin microparticles successfully encapsulated propolis extractive solution (PES) using spray-drying, creating a palatable dosage form. This method preserves propolis
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Propolis extractive solution (PES) possesses therapeutic properties but suffers from undesirable taste, odor, and ethanol content.
- Developing stable and palatable propolis dosage forms is crucial for its wider application.
Purpose of the Study:
- To prepare and optimize gelatin microparticles containing PES via spray-drying.
- To evaluate the effect of mannitol on microparticle characteristics and propolis activity.
- To assess the potential of these microparticles as a novel propolis delivery system.
Main Methods:
- Spray-drying technique was employed for microencapsulation of PES using gelatin.
- Optimization of spray-drying parameters and varying proportions of gelatin and mannitol were investigated.
- Particle morphology, size, entrapment efficiency, and antimicrobial activity against Staphylococcus aureus were analyzed.
Main Results:
- Mannitol addition resulted in regular microparticle morphology, preventing coalescence and agglomeration.
- Microparticle size averaged 2.70 µm without mannitol and 2.50 µm with mannitol.
- Entrapment efficiency reached up to 41% (without mannitol) and 39% (with mannitol).
- The spray-drying method effectively maintained propolis's antimicrobial activity against Staphylococcus aureus.
Conclusions:
- Gelatin microparticles prepared by spray-drying offer a promising method for encapsulating PES.
- Mannitol is crucial for achieving desirable microparticle morphology and characteristics.
- These microparticles can mask the unpleasant sensory attributes of PES, facilitating the development of improved propolis-based pharmaceutical formulations.