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Central nervous system-targeted complement inhibition mediates neuroprotection after closed head injury in transgenic
Mario Rancan1, Maria C Morganti-Kossmann, Scott R Barnum
1Department of Trauma Surgery, The Alfred Hospital and Monash University, Melbourne, Victoria, Australia.
Abstract:
The role of intracerebral complement activation after traumatic brain injury remains unclear. In this study, the authors demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood-brain barrier function after closed head injury compared with wild-type C57BL/6 littermates. This work further implicates the complement system as a participant in secondary progression of brain damage after head trauma and provides a strong rationale for future studies of posttraumatic pharmacologic complement inhibition.