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Published on: June 25, 2017
Insulin resistance: current therapeutic approaches
1Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Nagar, India.
Abstract:
Insulin resistance, an impaired biological response to either exogenous or endogenous insulin occurs in a majority of the diabetic population with type II diabetes. One of the current approaches for treating insulin resistance associated with NIDDM is the use of insulin sensitizing agents. Elucidation of the mechanism(s) of these agents may provide new targets for which selective ligands with better efficacy and low toxicity can be found.
Insights
Insulin resistance affects most type II diabetes patients. Understanding how insulin sensitizing agents work can reveal new drug targets for more effective and safer treatments.
Area of Science:
- Endocrinology
- Pharmacology
- Metabolic Diseases
Background:
- Insulin resistance is a key feature in type II diabetes, impacting how the body uses insulin.
- Current treatments for insulin resistance in type II diabetes often involve insulin sensitizing agents.
Purpose of the Study:
- To explore the mechanisms of action for insulin sensitizing agents.
- To identify potential new therapeutic targets for managing insulin resistance.
Main Methods:
- Literature review on insulin resistance and therapeutic agents.
- Analysis of existing data on insulin sensitizing drug mechanisms.
Main Results:
- Insulin sensitizing agents are a primary treatment for insulin resistance in type II diabetes.
- Understanding these agents' mechanisms is crucial for future drug development.
Conclusions:
- Further research into the mechanisms of insulin sensitizing agents can lead to novel therapeutic strategies.
- Identifying new targets may yield more effective and less toxic treatments for insulin resistance.
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