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Ocular manifestations of systemic lupus erythematosus in children

Sulaiman M Al-Mayouf1, Amal I Al-Hemidan

  • 1Department of Pediatrics, MBC-58, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia. mayouf@kfshrc.edu.sa

Saudi Medical Journal
|September 16, 2003
PubMed

Insights

Ocular manifestations are common in children with systemic lupus erythematosus (SLE). Optic neuropathy in these patients strongly predicts central nervous system (CNS) lupus involvement.

Area of Science:

  • Ophthalmology
  • Pediatrics
  • Rheumatology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
  • Ocular manifestations can significantly impact the quality of life in pediatric SLE patients.

Purpose of the Study:

  • To determine the prevalence and spectrum of ocular manifestations in children with SLE.
  • To examine correlations between ocular findings, disease activity, organ involvement, and autoantibodies.

Main Methods:

  • Cross-sectional study involving 52 children with SLE.
  • Comprehensive eye examinations, autoantibody testing, and SLE Disease Activity Index (SLEDAI) calculation.
  • Statistical analysis using Fisher exact test.

Main Results:

  • 34.6% of pediatric SLE patients had ocular manifestations.
  • Common findings included abnormal Schirmer's tests, retinal vascular lesions, iridocyclitis, optic neuropathy, and visual field defects.
  • Optic neuropathy showed a significant correlation with central nervous system (CNS) involvement (p<0.002).

Conclusions:

  • Ocular complications, including sight-threatening ones, are prevalent in pediatric SLE.
  • Optic neuropathy is a strong predictor of CNS lupus in children.
Abstract

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