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Updated: Jul 15, 2026

Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance
Published on: July 28, 2023
[Risk factors for Helicobacter pylori infection in children]
Mônica M C Moraes1, Gisélia A P da Silva
1Instituto Materno-Infantil de Pernambuco, Recife, PE, Brazil. gisapontes@uol.com.br
Insights
Helicobacter pylori infection is common in children, particularly school-aged ones. Poor sanitation and low income are linked to higher infection rates, highlighting environmental risk factors.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Helicobacter pylori infection is a significant global health concern, especially in pediatric populations.
- Understanding seroprevalence and associated risk factors is crucial for targeted interventions.
Purpose of the Study:
- To determine the seroprevalence of Helicobacter pylori infection among children.
- To identify environmental, social, economic, and health-related risk factors associated with H. pylori seropositivity in children.
Main Methods:
- A cross-sectional study involving 228 children at a pediatric outpatient clinic.
- Data collection through parental interviews covering demographics, environmental conditions, socioeconomic status, and health history.
- Nutritional status assessed using anthropometric indices.
Main Results:
- Overall H. pylori seroprevalence was 32%, with higher rates in school-aged children (39.4%) compared to preschool children (25.8%).
- Significant risk factors for seropositivity included lack of toilet facilities, overcrowding, lower family income, and lower maternal education levels.
- No significant association was found with health indicators, nutritional status, or contact with individuals experiencing gastrointestinal issues.
Conclusions:
- The study reveals a high seroprevalence of H. pylori infection in the studied pediatric population.
- Environmental factors, such as poor sanitation and socioeconomic status, are significantly associated with increased H. pylori seropositivity in children.
Objective:
To establish the seroprevalence of Helicobacter pylori infection in children and to identify risk factors for seropositivity.\par
Methods:
A cross-sectional study established the seroprevalence of infection by Helicobacter pylori and afterwards a comparative study was performed amongst seropositive and seronegative children. A group of 228 children were cared for at the outpatient clinic of Instituto Materno Infantil de Pernambuco, from May to July 1999. Age, sex, indicators of environmental, social and economic conditions, health and nutritional status as well as children living in contact with dwellers with history of gastrointestinal pain or peptic disease were evaluated. All data was obtained through an interview with children's parents or caretakers. Nutritional status was evaluated by anthropometric index. \par
Results:
Seroprevalence of infection caused by Helicobacter pylori was found in 32% (95% CI 26% - 38%); 25.8% (95% CI 17.8% - 33.8%) in preschool children and 39.4% (95% CI 30.4% - 48.4%) in school age children. Analysis of environmental variables demonstrated higher frequency of seropositivity in children living in houses without toilets or sanitary flush toilet facilities (p = 0.008), overcrowded (p = 0.05), lower family income (p = 0.03) and poor maternal education (p = 0.002). There were no statistically significant differences between the groups regarding health indicators, anthropometric indexes and children living with dwellers with history of gastritis or peptic ulcer.\par
Conclusion:
Seroprevalence of Helicobacter pylori infection was high in the studied population, being even higher among the school age group. A positive association between seropositivity and less favorable environmental variables was detected.
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