Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymph node hyalinization in elderly Japanese.

I Taniguchi1, G Murakami, A Sato

  • 1Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.

Histology and Histopathology
|September 16, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

T cell-mediated inhibition of erythropoiesis in myelodysplastic syndromes.

American journal of hematology·1992
Same author

[A case of eosinophilic pneumonia with diffuse reticular shadows and scattered nodular shadows on chest X-ray film--comparison of findings of chest X-ray and lung histology].

Nihon Kyobu Shikkan Gakkai zasshi·1992
Same author

Depending on the mode of application morphine enhances or depresses somatocardiac sympathetic A- and C-reflexes in anesthetized rats.

Neuroscience research·1992
Same author

Insulin insensitivity in nonobese, nondiabetic essential hypertension and its improvement by an alpha 1-blocker (bunazosin).

American journal of hypertension·1992
Same author

Human sera from varicella-zoster virus (VZV) infections cross-react with human T cell leukaemia virus type 1 (HTLV-1): common epitopes in VZV gene 22 protein and HTLV-1 p19 gag protein.

The Journal of general virology·1992
Same author

Mechanism of the reflex inhibition of micturition contractions of the urinary bladder elicited by acupuncture-like stimulation in anesthetized rats.

Neuroscience research·1992

Lymph node hyalinization presents two distinct types: mediastinal and pelvic, differing in collagen fiber size and location. These age-related changes significantly impair lymph node function.

Area of Science:

  • Pathology
  • Immunology
  • Aging Research

Background:

  • Lymph node hyalinization is a common age-related change.
  • Two distinct types, mediastinal and pelvic, have been observed in lymph nodes.

Purpose of the Study:

  • To investigate the characteristics and potential origins of mediastinal-type and pelvic-type lymph node hyalinization.
  • To compare the incidence of these hyalinization types between elderly Japanese and white Americans.

Main Methods:

  • Microscopic examination of lymph node specimens from elderly Japanese and white Americans.
  • Histological analysis of collagen fibril size and composition.
  • Immunohistochemical staining for Factor VIII.

Main Results:

Related Experiment Videos

  • Mediastinal-type hyalinization (onion-peel lesions) found in thoracic nodes, composed of thin collagen fibrils.
  • Pelvic-type hyalinization (eosinophilic, glassy lesions) found in pelvic nodes, composed of thick collagen fibrils.
  • Mediastinal-type hyalinization more frequent in Japanese, associated with anthracosis; pelvic-type hyalinization more common in white Americans, linked to vascular degeneration.

Conclusions:

  • Lymph node hyalinization exhibits distinct morphological and etiological characteristics based on location and ethnicity.
  • Anthracosis may contribute to mediastinal-type hyalinization, while vascular degeneration is implicated in pelvic-type hyalinization.
  • These age-related hyalinization processes significantly reduce lymph node filtration capacity.