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Related Experiment Videos

Clinical trials with bisphosphonates.

A Lombardi1, A C Santora

  • 1Clinical Research-Endocrinology and Metabolism, Merck Research Laboratories, Rahway, NJ.

Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna
|July 1, 1992
PubMed
Summary

Bisphosphonates inhibit bone resorption for osteoporosis treatment. Newer agents like alendronate show improved efficacy and tolerability over older drugs such as etidronate.

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Area of Science:

  • Pharmacology
  • Orthopedics
  • Bone Metabolism

Background:

  • Bisphosphonates are pyrophosphate analogs that inhibit bone resorption.
  • They are used for Paget's disease, hypercalcemia of malignancy, and metastatic bone disease.
  • Bisphosphonates are increasingly used for osteoporosis treatment and prevention.

Purpose of the Study:

  • To review the efficacy and safety of bisphosphonates in treating bone loss.
  • To compare different bisphosphonate agents for osteoporosis management.

Main Methods:

  • Review of clinical trials and therapeutic applications of bisphosphonates.
  • Analysis of bone mineral density changes and fracture rates.
  • Evaluation of side effect profiles and histological effects.

Main Results:

  • Etidronate increased vertebral bone mass but plateaued and potentially impaired bone formation.
  • Newer bisphosphonates selectively inhibit resorption without negative effects on bone histology.
  • Pamidronate increased bone mass in osteoporosis patients, sustained for years, but had GI tolerability issues.
  • Alendronate increased vertebral bone mass in postmenopausal patients and appears more potent and better tolerated than pamidronate.

Conclusions:

  • Bisphosphonates are effective in treating conditions with increased bone turnover, including osteoporosis.
  • Newer bisphosphonates offer improved efficacy and tolerability for managing osteoporosis.
  • Alendronate shows promise as a potent and well-tolerated option for postmenopausal osteoporosis.

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