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[Hypertension and cardiovascular damage].

A Zanchetti1

  • 1Istituto di Clinica Medica Generale e Terapia Medica, Università degli Studi di Milano.

Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna
|July 1, 1992
PubMed
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Antihypertensive therapy trials often focus on cardiovascular events, neglecting lesion prevention. New methods can assess if certain drugs, like calcium-channel blockers, better prevent or regress atherosclerotic plaques.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hypertension Research

Context:

  • Major randomized trials for antihypertensive therapy primarily use cardiovascular events as endpoints.
  • This focus has limited understanding of therapy's role in preventing underlying cardiovascular lesions.
  • Current understanding is insufficient regarding the prevention or regression of atherosclerotic plaques by antihypertensive agents.

Purpose:

  • To evaluate the effectiveness of antihypertensive therapy in preventing cardiovascular lesions.
  • To determine if specific drug classes, such as calcium-channel blockers, are more effective than traditional agents in managing atherosclerotic plaques.
  • To explore the potential for regression of atherosclerotic plaques using antihypertensive treatments.

Summary:

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  • Quantitative evaluation methods for organ damage in hypertension are now available.
  • Non-invasive techniques like quantitative ultrasonography of carotid artery walls can be utilized in large trials.
  • These methods allow for assessing the impact of antihypertensive drugs on atherosclerotic plaque development and regression.

    • Impact:

    • Provides crucial data on the primary goal of therapy for mild to moderate hypertensives: prevention of cardiovascular lesions.
    • Offers insights into whether specific antihypertensive drug classes offer superior benefits in managing atherosclerosis.
    • Enables more targeted and effective therapeutic strategies for hypertension management and cardiovascular disease prevention.