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Salivary gland function in persons with ectodermal dysplasias.

Hilde Nordgarden¹, Kari Storhaug, Staale Petter Lyngstadaas

¹Department of Oral Surgery and Oral Medicine, Institute of Clinical Dentistry, Oslo, Norway. hilde.nordgaren@tako.dep.no

European Journal of Oral Sciences

|September 17, 2003

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Ectodermal dysplasias (EDs) can impair salivary gland function, with many patients showing reduced saliva flow and altered protein output. Salivary testing is recommended for individuals with suspected EDs.

Area of Science:

Oral Medicine
Genetics
Developmental Biology

Background:

Ectodermal dysplasias (EDs) are a group of genetic disorders affecting ectodermal derivatives.
Salivary gland dysfunction is a potential, yet understudied, manifestation of EDs.

Purpose of the Study:

To investigate salivary gland function in individuals with Ectodermal Dysplasias (EDs).
To compare salivary parameters between ED patients and healthy controls.

Main Methods:

Studied 39 patients with EDs and 39 age/sex-matched controls.
Assessed stimulated submandibular and parotid salivary flow rates.
Analyzed salivary protein concentrations and output (total protein, acidic proline-rich proteins, histatins).

Main Results:

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33% of ED patients exhibited reduced submandibular and/or parotid saliva secretion.
ED group showed reduced median submandibular salivary secretory rate.
Submandibular glands appeared more affected than parotid glands in EDs.

Conclusions:

Salivary gland hypofunction is a significant finding in Ectodermal Dysplasias.
Salivary secretory tests are recommended for diagnosing and managing EDs.
Submandibular gland involvement is prominent in ED-associated salivary dysfunction.