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Related Experiment Videos

Dendritic cells and fungi.

Eva Buentke1, Annika Scheynius

  • 1Department of Medicine, Unit of Clinical Allergy Research, Karolinska Institutet, Stockholm, Sweden.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|September 17, 2003
PubMed
Summary

Fungi are increasingly causing human disease, acting as opportunistic pathogens. Dendritic cells (DCs) link innate and adaptive immunity, crucial for recognizing fungal pathogens and initiating immune responses.

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Area of Science:

  • Immunology
  • Mycology
  • Infectious Diseases

Background:

  • Fungi are emerging as significant human pathogens and allergens.
  • Dendritic cells (DCs) bridge innate and adaptive immunity, essential for pathogen recognition.
  • Effective host defense relies on discriminating between pathogens for tailored immune responses.

Purpose of the Study:

  • To review the role of dendritic cells in anti-fungal immunity.
  • To explore how fungi activate DCs and influence T cell responses.
  • To discuss the potential of ex vivo-generated DCs for therapeutic applications.

Main Methods:

  • Review of studies on fungal-DC interactions.
  • Analysis of Toll-like receptor (TLR) signaling in response to fungi.
  • Examination of DC maturation and cytokine production upon fungal stimulation.

Main Results:

  • Fungi or fungal factors potently activate DCs, leading to maturation.
  • Activated DCs upregulate co-stimulatory molecules and produce cytokines.
  • This results in distinct T cell responses, influencing cell-mediated immunity.

Conclusions:

  • DCs are pivotal in initiating cell-mediated immune responses against fungi.
  • Fungal activation of DCs shapes adaptive immunity towards fungi.
  • Therapeutic use of ex vivo-generated DCs for anti-fungal immunity is a future prospect.

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