Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Autoimmune hemolytic anemia with complement-positive direct antiglobulin test].

S Martínez Nadal1, I Alcorta Loyola, J Estella Aguado

  • 1Servicio de Pediatría, Hospital Universitari Sant Joan de Déu, Universidad de Barcelona, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|September 17, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Update on L-asparaginase treatment in paediatrics].

Anales de pediatria (Barcelona, Spain : 2003)·2013
Same author

[Giant splenomegaly due to juvenile myelomonocytic leukaemia].

Anales de pediatria (Barcelona, Spain : 2003)·2009
Same author

[Cord blood levels of interleukin 6 in preterm infants as an early marker of neonatal morbidity].

Anales de pediatria (Barcelona, Spain : 2003)·2008
Same author

[Dry lung syndrome in a neonate].

Anales de pediatria (Barcelona, Spain : 2003)·2006
Same author

[Topiramate and pregnancy. Neonate with bone anomalies].

Anales de pediatria (Barcelona, Spain : 2003)·2005
Same author

[Postvaricella purpura fulminans].

Anales de pediatria (Barcelona, Spain : 2003)·2004

Autoimmune hemolytic anemia (AIHI) is rare in children. Diagnosis relies on the direct antiglobulin test (DAT), identifying immunoglobulin or complement involvement, guiding treatment for this uncommon condition.

Area of Science:

  • Pediatric Hematology
  • Immunology
  • Clinical Diagnostics

Background:

  • Autoimmune hemolytic anemia (AIHI) is a rare condition in children.
  • Diagnosis involves the direct antiglobulin test (DAT) to identify the causative globulin (IgG or complement).
  • Determining the specific globulin and etiology is crucial for effective treatment.

Observation:

  • Presents three pediatric AIHI cases with complement-positive DAT.
  • Etiologies included warm antibody (IgG-negative DAT), infectious mononucleosis with cold agglutinins, and Donath-Landsteiner antibodies.
  • All patients received initial corticosteroid therapy.

Findings:

  • Diverse etiologies of AIHI can present with a complement-positive DAT.
  • The specific cause of AIHI influences treatment decisions.

Related Experiment Videos

  • Corticosteroid treatment was adjusted based on the confirmed etiology.

    • Implications:

    • Highlights the importance of comprehensive laboratory workup for pediatric AIHI.
    • Emphasizes tailored treatment strategies based on identified AIHI causes.
    • Contributes to understanding the varied presentations and management of pediatric AIHI.