Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Effect of elastin peptides on cell proliferation].

A F Ghuysen-Itard1, L Robert, M P Jacob

  • 1Laboratoire de Biologie du Tissu conjonctif, U.R.A.-C.N.R.S, n 1460, Faculté de Médecine, Université Paris-XII, Créteil.

Comptes Rendus De L'Academie Des Sciences. Serie III, Sciences De La Vie
|January 1, 1992
PubMed
Summary

Elastin peptides stimulate cell proliferation by activating cell membrane receptors. Their effects vary by cell type and concentration, suggesting a role in physiological and pathological conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Celebration of the 50th anniversary of the foundation of the French society for connective tissue research. Its short history in the frame of the origin and development of this discipline.

Pathologie-biologie·2012
Same author

Fifty years of structural glycoproteins.

Pathologie-biologie·2012
Same author

[Pathologie Biologie: an evolution].

Pathologie-biologie·2011
Same author

Physiology of skin aging.

Clinics in plastic surgery·2011
Same author

The Maillard reaction--illicite (bio)chemistry in tissues and food.

Pathologie-biologie·2011
Same author

[The connective tissues, from the origin of the concept to its "Maturation" to extracellular matrix. Application to ocular tissues. Contribution to the history of medical sciences].

Pathologie-biologie·2011

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Context:

  • Elastin peptides interact with cell membrane receptors coupled to G-proteins, initiating intracellular signaling cascades.
  • Activation of phospholipase C leads to increased inositol trisphosphate (IP3) and diacylglycerol (DAG), and opens calcium channels.
  • Growth factors utilize similar intracellular calcium modifications, prompting investigation into elastin peptides' mitogenic potential.

Purpose:

  • To investigate the effect of elastin peptides on cell proliferation.
  • To determine the dose-dependent effects of elastin peptides on fibroblast proliferation.
  • To explore the influence of peptide concentration, molecular weight, and origin on cell growth.

Summary:

  • Elastin peptides were found to modulate cell proliferation, with varying effective concentrations (1 microgram/ml to 10 mg/ml) depending on cell origin and peptide type.

Related Experiment Videos

  • CCL 39 chinese hamster lung fibroblasts showed enhanced proliferation in response to 3-10 mg/ml elastin peptides.
  • Human skin fibroblasts exhibited enhanced proliferation between 0.5-3.3 mg/ml, but inhibition at higher concentrations, irrespective of peptide molecular weight (10-75 kDa).

    • Impact:

    • Findings suggest that specific elastin peptide fractions possess growth-promoting properties, while others may inhibit proliferation, with conformation playing a potential role.
    • Circulating elastin peptides in human sera (1.0-10 micrograms/ml) increase in obstructive arteriopathies and hyperlipidemias.
    • These results indicate a potential physiopathological role for elastin peptides in regulating cell proliferation in both normal and pathological states.