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Effect of left ventricular function on long-term left ventricular pacing and sensing threshold.
Hung-Fat Tse1, Cannas Yu, Vince E Paul
1Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
Summary
Left ventricular systolic function impacts long-term left ventricular pacing thresholds. Patients with reduced ejection fraction experienced higher pacing thresholds after three months compared to those with normal function.
Area of Science:
- Cardiology
- Biomedical Engineering
Background:
- The long-term effects of left ventricular (LV) systolic function on pacing and sensing thresholds are not well understood.
- Assessing LV systolic function's impact is crucial for optimizing cardiac device therapy.
Purpose of the Study:
- To investigate the relationship between left ventricular ejection fraction (LVEF) and LV pacing/sensing thresholds.
- To compare long-term pacing and sensing parameters in patients with and without LV systolic dysfunction.
Main Methods:
- A cohort of 56 patients undergoing permanent LV pacing was studied.
- Patients were divided into two groups based on LVEF (<40% vs. >40%) and followed for 3 months.
- LV pacing thresholds, sensing thresholds, and lead impedance were measured at implant and follow-up.
Main Results:
- Patients with LVEF <40% had lower R wave amplitude at implant but similar pacing thresholds and impedance.
- At 3-month follow-up, patients with LVEF <40% showed significantly higher LV pacing thresholds.
- No significant differences in sensing thresholds or lead impedance were observed between groups.
Conclusions:
- LV systolic function significantly influences long-term LV pacing thresholds.
- Left ventricular systolic dysfunction is associated with an increase in LV pacing thresholds post-implant.