Related Experiment Video
Updated: Sep 20, 2026

Real-Time Imaging of CCL5-Induced Migration of Periosteal Skeletal Stem Cells in Mice
Published on: September 16, 2020
Role of perlecan in skeletal development and diseases
John Hassell1, Yoshihiko Yamada, Eri Arikawa-Hirasawa
1The Center for Research in Skeletal Development and Pediatric Orthopaedics, Shriners Hospitals for Children, Tampa, FL 33612, USA. jhassell@shctampa.usf.edu
Abstract:
Perlecan, a large heparan sulfate proteoglycan (HSPG), is present in the basement membrane and other extracellular matrices. Its protein core is 400 kDa in size and consists of five distinct structural domains. A number of in vitro studies suggest multiple functions of perlecan in cell growth and differentiation and tissue organization. Recent studies with gene knockout mice and human diseases revealed critical in vivo roles of perlecan in cartilage development and neuromuscular junction activity.
More Related Videos
Related Concept Videos
Cytoskeletal Linker Proteins - Plakins
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...
Pleiotropy
Bone Formation by Endochondral Ossification
Canonical Wnt Signaling Pathway
Bone Remodeling and Repair

