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[Glutamatergic hypothesis of schizophrenia]
Rodrigo A Bressan1, Lyn S Pilowsky
1Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP). São Paulo, SP, Brasil. r.bressan@iop.kcl.ac.uk
Revista Brasileira De Psiquiatria (Sao Paulo, Brazil : 1999)
|September 17, 2003
Summary
Schizophrenia involves both dopamine and glutamate system dysfunctions. This review highlights N-methyl-D-aspartate (NMDA) receptor hypofunction and its link to hyperdopaminergic states in schizophrenia.
Area of Science:
- Neuroscience
- Psychiatry
- Neurobiology
Context:
- Schizophrenia pathophysiology remains unclear.
- Dopamine dysfunction is established, but glutamate involvement is increasingly evident.
- Glutamatergic system, particularly NMDA receptors, plays a crucial role.
Purpose:
- To review glutamatergic system functioning, focusing on NMDA receptors.
- To present evidence for glutamatergic dysfunction, specifically NMDA receptor hypofunction, in schizophrenia.
- To discuss the interplay between dopaminergic and glutamatergic systems in schizophrenia.
Summary:
- This paper details N-methyl-D-aspartate (NMDA) receptor function and its hypofunction in schizophrenia.
- It explores the connection between the hyperdopaminergic state in schizophrenia and glutamatergic dysfunctions.
- Evidence suggests NMDA receptor hypofunction contributes to schizophrenia's complex neurobiology.
Impact:
- Provides insights into schizophrenia's neurobiological underpinnings.
- Highlights the therapeutic potential of targeting the glutamatergic system.
- Enhances understanding of neurotransmitter system interactions in psychiatric disorders.
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