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[Correlation of antianginal effect of corinfar and diastolic function in patients with ischemic heart disease]
Insights
Corinfar improves exercise tolerance in coronary heart disease patients by normalizing left ventricular stiffness. This drug enhances coronary reserve, offering an important antianginal mechanism.
Area of Science:
- Cardiology
- Pharmacology
Context:
- Coronary heart disease (CHD) affects left ventricular function.
- Assessing drug effects on cardiac mechanics is crucial.
Purpose:
- To investigate the effects of corinfar on left ventricular function and exercise tolerance in CHD patients.
- To determine the mechanism of corinfar's antianginal effect.
Summary:
- Corinfar (30 mg) did not alter normal diastolic function in CHD patients.
- The drug normalized left ventricular stiffness, increasing coronary reserve and exercise capacity.
- Reduced left ventricular stiffness may indicate suitability for corinfar therapy.
Impact:
- Corinfar's ability to improve ventricular stiffness offers a novel therapeutic approach for CHD.
- Enhanced exercise tolerance and coronary reserve contribute to corinfar's antianginal benefits.
Abstract:
The study was undertaken to examine 45 patients with coronary heart disease and 14 healthy subjects by using radionuclide ventriculography, apex- and echocardiographies, bicycle ergometry, transesophageal electrocardiostimulation before therapy and at the action peak of corinfar in a dose of 30 mg. It was shown that corinfar failed to affect the unaltered diastolic function of the left ventricle. The normalizing effect of corinfar on left ventricular stiffness was found to result in higher coronary reserve, significantly enhanced exercise tolerance and to be an important mechanism of antianginal effect of the drug. Impaired left ventricular stiffness may be an additional criterion for using corinfar in patients with coronary heart disease.