[Weight gain during antidepressant therapy]

Changes of weight were assessed within a population of 329 patients with major depressive disorders and neurotic states, treated with amitriptyline, doxepin, insidone and imipramine. It has been found that the most important increase of body weight occurred in the groups of patients treated with amitriptyline and doxepin. In the group of insidone the increase of weight was not so high as in the previous groups. The patients treated with imipramine lost weight in the first three weeks of the treatment. No relationship between the increase of body weight and diagnosis, doses of antidepressants, age, sex and education has been observed.