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Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
The automation of dissolution testing of solid oral dosage forms
E Lamparter1, C H Lunkenheimer
1Department of Pharmaceutical Research and Development, Boehringer Ingelheim KG, Rhein, Germany.
Journal of Pharmaceutical and Biomedical Analysis
|October 1, 1992
Summary
A new automated dissolution testing system (AUTO DISS) enables on-line determination of active ingredient concentration. This system integrates an automatic sampler with various analytical instruments for efficient drug dissolution analysis.
Area of Science:
- Pharmaceutical Technology
- Analytical Chemistry
- Drug Delivery Systems
Background:
- Dissolution testing is critical for pharmaceutical product development and quality control.
- Accurate and efficient dissolution analysis is essential for ensuring drug efficacy and safety.
Purpose of the Study:
- To present a fully automated system for dissolution testing, named AUTO DISS.
- To describe the components and capabilities of the AUTO DISS system for on-line analysis.
Main Methods:
- The AUTO DISS system integrates an automatic sampler with analytical instruments.
- On-line determination of active ingredient concentration using UV-Vis spectrometry, liquid chromatography, and flow injection analysis (FIA).
Main Results:
- The system's suitability was demonstrated through the dissolution testing of brotizolam from tablets using FIA.
- Bepafant dissolution from capsules was successfully analyzed using diode-array spectroscopy.
Conclusions:
- The AUTO DISS system provides a robust and automated solution for dissolution testing.
- The integrated analytical capabilities allow for efficient on-line monitoring of drug release profiles.
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