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Electrochemical behaviour of tizanidine at solid electrodes
J M Kauffmann1, B Lopez Ruiz, M F Gotor
1Université Libre de Bruxelles, Institut de Pharmacie, Belgique.
Journal of Pharmaceutical and Biomedical Analysis
|October 1, 1992
Summary
This study details the electrochemical behavior of tizanidine, a muscle relaxant, using a carbon paste electrode. Researchers identified oxidation sites and reduction products, enabling quantitative analysis of tizanidine concentrations.
Area of Science:
- Electrochemistry
- Analytical Chemistry
- Pharmacology
Background:
- Tizanidine is a centrally-acting skeletal muscle relaxant.
- Understanding its electrochemical properties is crucial for analytical applications.
- Carbon paste electrodes (CPE) offer a versatile platform for electrochemical studies.
Purpose of the Study:
- To investigate the electrochemical behavior of tizanidine in aqueous media.
- To identify the oxidation and reduction sites and products of tizanidine.
- To develop a quantitative method for tizanidine determination.
Main Methods:
- Cyclic voltammetry at various pH levels.
- Controlled potential coulometry.
- Comparative studies with related molecules.
- Differential pulse voltammetry for quantification.
Main Results:
- The oxidation site of tizanidine was identified, with proposed oxidation products in acidic media.
- Electrochemical reduction occurred in a single irreversible step, yielding a detectable diamine derivative.
- A quantitative method for tizanidine was established within the concentration range of 2 x 10(-5) M to 1 x 10(-4) M.
Conclusions:
- The electrochemical behavior of tizanidine at the CPE is well-defined.
- The study provides insights into tizanidine's redox pathways.
- The developed differential pulse voltammetry method is suitable for quantitative analysis of tizanidine.
