[A comparative morphometric and DNA content study of endometrial hyperplasia and adenocarcinoma]

The DNA content and morphometric study of four groups of endometrial proliferations were compared: adenomatous hyperplasia (21 cases), atypical hyperplasia (13 cases), adenocarcinomas with superficially myometrial invasion (9 cases) and with deep myometrial invasion (8 cases). The normal DNA histogram patterns were identified in the majority of the adenomatous hyperplasia. The important difference between proliferative and neoplastic endometrium was the size and shape of nuclei of epithelial cells. The DNA content and morphometric measurement of atypical hyperplasia and well-differentiated adenocarcinomas were similar. The highest proportions of cells with polyploidy were found in the deep invasive carcinomas. The study suggests the DNA content determination and morphometry are useful supplementary methods for observing the continuous pathologic process.