Related Experiment Video
Updated: Aug 15, 2026
07:32
Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
Published on: September 30, 2019
Interactions of FGFs with target cells
D Ledoux1, L Gannoun-Zaki, D Barritault
1Laboratoire de Recherche sur la Croissance Cellulaire, La Réparation et la Régénération Tissulaires, Jeune Formation INSERM n 9014, Université Paris XII-Val de Marne, Creteil, France.
Progress in Growth Factor Research
|January 1, 1992
Summary
Fibroblast growth factors (FGFs) 1 and 2 are crucial for cell communication and organism development. This review details their receptors and intracellular pathways, highlighting their broad biological activities.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Growth factors are essential for cellular communication in multicellular organisms.
- Fibroblast growth factors (FGFs) are key polypeptides involved in development.
- FGFs 1 and 2 (acidic and basic FGFs) are abundant and widely studied.
Purpose of the Study:
- To review the characterization of FGF receptors and intracellular pathways.
- Focus on the roles and mechanisms of FGFs 1 and 2.
Main Methods:
- Literature review of existing research on FGFs 1 and 2.
- Analysis of studies on FGF receptor interactions and signaling pathways.
Main Results:
- FGFs 1 and 2 exhibit ubiquitous distribution and diverse biological activities.
- These activities include regulating cellular proliferation, differentiation, neurotrophic, and angiogenic effects.
- FGFs interact with specific cell surface receptors, leading to internalization and activation of intracellular pathways.
Conclusions:
- FGFs 1 and 2 are critical regulators of cellular processes.
- The existence of high and low affinity receptors for FGFs has been suggested.
- Further characterization of FGF-receptor interactions and downstream signaling is ongoing.
More Related Videos
Related Concept Videos
02:38Mitogens and the Cell Cycle
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
01:15Receptor Downregulation in MVBs
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
01:19Interactions Between Signaling Pathways
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
01:22Amplifying Signals via Enzymatic Cascade
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze the...
01:16TGF - β Signaling Pathway
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
01:17Intracellular Signaling Affects Focal Adhesions
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...