[Further studies of collagen biosynthesis by hepatocytes]

Electron microscopic observation was carried out on 32 biopsies from liver and biliary system diseases. It was found that proliferative collagen in the liver was located not only in the portal space and Disse space, but also in the hepatocytes. Most of the collagen seen in hepatocytes were in the form of collagen fibrils, oriented irregularly, intermingled with the organelles and without a delimiting membrane. Therefore, the authors suggest that these collagen fibrils were produced by the hepatocytes themselves.