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Chemoelastic effect of membranes.

H Gruler

    Zeitschrift Fur Naturforschung. Section C, Biosciences
    |September 1, 1975
    PubMed
    Summary

    Membrane molecules with intrinsic splay and polar orientation create spontaneous curvature. Environmental changes induce chemoelastic effects, altering cell shape and causing protein clustering.

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    Area of Science:

    • * Biophysics and Soft Matter Physics
    • * Polymer Science and Materials Chemistry

    Background:

    • * Uniaxial membranes in asymmetric environments exhibit spontaneous splay deformation.
    • * Intrinsic molecular properties like wedge shape and polar orientation contribute to membrane curvature.
    • * The chemoelastic effect links environmental asymmetry to membrane curvature via molecular orientation and intrinsic splay.

    Purpose of the Study:

    • * To elucidate the mechanisms behind spontaneous splay deformation in membranes.
    • * To explain the chemoelastic effect in polyelectrolytes and its relation to spontaneous curvature.
    • * To model the interaction and forces between objects within a membrane and apply it to biological phenomena like protein clustering.

    Main Methods:

    • * Theoretical analysis based on elastic theory of membranes.
    • * Mathematical modeling of molecular orientation and intrinsic splay.
    • * Development of a model for interacting conical bodies within a uniaxial membrane.

    Main Results:

    • * Asymmetric environments induce spontaneous splay deformation due to molecular properties.
    • * A small pH change (0.1) can induce significant spontaneous curvature (10^4 cm^-1) in polyelectrolytes.
    • * The proposed model demonstrates attractive or repulsive forces between embedded objects, explaining protein clustering.

    Conclusions:

    • * Spontaneous membrane curvature is governed by molecular structure and environmental asymmetry.
    • * The chemoelastic effect provides a mechanism for environmental control of membrane shape, applicable to red blood cells.
    • * The model of interacting bodies offers insights into collective behaviors like protein aggregation within membranes.

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