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Related Experiment Videos

[Methods for measuring spinal cord blood flow].

A M Bidabé1, A M Gin, V Pointillart

  • 1Service de Neuroradiologie, CHR de Bordeaux.

Annales Francaises D'Anesthesie Et De Reanimation
|January 1, 1992
PubMed
Summary
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This review covers animal methods for measuring spinal cord blood flow (SCBF) and introduces a new non-invasive technique for humans. SCBF appears regulated similarly to cerebral blood flow, with potential applications for spinal lesion studies.

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Physiology

Background:

  • Current animal methods for measuring spinal cord blood flow (SCBF) are invasive and yield variable results.
  • SCBF regulation appears analogous to cerebral blood flow, influenced by chemical, autoregulatory, and metabolic factors.

Purpose of the Study:

  • To review existing animal techniques for SCBF measurement.
  • To introduce and evaluate a novel non-invasive method for SCBF assessment in humans using stable xenon-enhanced computed tomographic imaging (Xes-CT).

Main Methods:

  • Review of invasive animal techniques: hydrogen clearance, labelled microspheres, 133Xe clearance, and 14C-antipyrine autoradiography.
  • Application of stable xenon-enhanced computed tomographic imaging (Xes-CT) based on Fick's principle for human SCBF measurement.

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  • Quantitative analysis of SCBF in eight human subjects using a series of CT scans during xenon inhalation.

    • Main Results:

    • Animal methods show significant variability in SCBF measurements based on technique, spinal level, and species.
    • Quantitative analysis in humans yielded a mean SCBF of 58.8 +/- 5.96 ml x 100 g-1 x min-1.
    • The Xes-CT method, while non-invasive and reproducible, exhibits a low signal-to-noise ratio and demonstrates tissue heterogeneity.

    Conclusions:

    • SCBF is likely regulated by factors similar to cerebral blood flow.
    • The non-invasive Xes-CT method holds promise for studying spinal cord ischemia in humans.
    • Further technical and software improvements are needed for optimal Xes-CT application in SCBF measurement.