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[Is the centrosome a dynamic structure?].

M Moudjou1, M Bornens

  • 1Centre de Générique moléculaires du C.N.R.S., Gif-sur-Yvette.

Comptes Rendus De L'Academie Des Sciences. Serie III, Sciences De La Vie
|January 1, 1992
PubMed
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Calcium ions (Ca++) influence human centrosome organization by altering pericentriolar material distribution and reducing intercentriolar distance. This suggests potential structural plasticity within centrioles, impacting cell division.

Area of Science:

  • Cell Biology
  • Cytoskeleton Dynamics
  • Centrosome Structure

Context:

  • Human centrosomes are critical for cell division and organization.
  • Previous studies established centrosome structure without fully considering ionic effects.
  • The role of calcium ions (Ca++) in centrosome organization remained unclear.

Purpose:

  • To investigate the effects of Ca++ on human centrosome organization.
  • To explore modifications in centrosome structure under varying ionic conditions.
  • To understand the potential for structural plasticity within centrosomes.

Summary:

  • Millimolar concentrations of Ca++ alter the distribution of pericentriolar material (PCM) and decrease intercentriolar distance in isolated human centrosomes.
  • Modifying the isolation method to exclude EDTA revealed structural differences, including decreased centriole diameter.

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  • This decrease is attributed to transverse sliding of microtubule triplets, suggesting intra-centriole movement.

    • Impact:

    • Reveals a novel regulatory mechanism for centrosome organization involving Ca++.
    • Suggests that centrosomes possess inherent structural plasticity, potentially influencing their function.
    • Provides new insights into the dynamic nature of centrioles and their components.