[Immune response to hepatitis B revaccination in children]

In this report, we investigated the efficacy of revaccination with hepatitis B vaccine in thirty-eight children after primary immunization. The results showed that anti-HBs immune response developed in 37 children after revaccination. with a response rate of 97.4% (37/38). The geometric mean titres (GMTs) of anti-HBs at 3rd weeks, 3rd and 6th month after the booster dose reached 824.1, 407.7 and 193.6IU/L, which were 24.5, 12.1 and 5.8 times higher than those before the booster dose (33.6IU/L), respectively. The peak levels reached at 3rd week after revaccination. However anti-HBs levels declined rapidly, the percentage of antibody decrease were 50.5%, 76.5% at 3rd and 6th month after booster dose respectively. The immune response to revaccination gave a strong correlation to the primary immunization. In conclusion, our findings indicated that a good response to revaccination with a dose of 10 micrograms of hepatitis B vaccine in children were observed.