Multiple projection of vagal non-myelinated afferents to the anterior insular cortex in rats

Projection of the vagal C-afferent to the insular cortex was examined in rats. Electrical activation of the C-afferent resulted in two cortical field potentials in the anterior insula. They were independent of each other and neither of them was attributed to the specific thalamic projection. These results imply that vagal information is conveyed to the cerebral cortex by more than one pathways.