[Correlation between the brain serotonin and the hypothalamic neuro-secretion in rat (author's transl)]

Parenteral administration of PCPA (200 mg/kg) induces changes in the quantitiy and the distribution of hypothalamic neurosecretion. This action appears very quickly and increases during the 48 hours following the injection. The histologic observations disclose a large accumulation of neurosecretory material in the supraoptic nuclei and in the accessory magnocellular groups of the anterior hypothalamus. In the median eminence large Herring bodies are seen. These results are to be compared to those obtained after mesencephalic raphes lesioning. The histologic alterations observed in the anterior hypothalamic level, may be due to complex disturbances involving the monoaminergic neuromediation.