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Updated: Sep 14, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 31, 2013
[Signet-ring cell adenocarcinoma involving the bladder and the rectum. Apropos of two cases]
E Letessier1, A Hamy, P Cuillière
1Service de Chirurgie Générale I, Hôpital G. et R. Laënnec, Nantes.
Abstract:
Two cases of primary signet-ring cell carcinoma involving the urinary bladder, with invasion of the rectum, are presented. Pelvic exenterations were performed, followed by a rapidly fatal outcome (6 and 7.5 months). These cases of signet-ring cell carcinoma of the bladder were reviewed with 33 previously reported cases in the literature. The clinical characteristics, histologic findings, pathogenesis, and effectiveness of aggressive treatment of this rare bladder malignancy are discussed.
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