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[Antibiotic therapy in children with pertussis]
Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
|November 1, 1992
Summary
Antibiotics like erythromycin are effective for early pertussis (whooping cough) treatment in infants. However, antibiotics do not prevent later complications and may increase risks when used during the spastic phase.
Area of Science:
- Pediatrics
- Infectious Diseases
- Pharmacology
Context:
- Pertussis (whooping cough) treatment guidelines require updates based on recent data.
- Antibiotic therapy aims to prevent Bordetella pertussis colonization in the respiratory tract.
Purpose:
- To compare the efficacy of erythromycin and ampicillin in infants with pertussis during the first two weeks of illness.
- To evaluate the preventative effect of antibiotic therapy during the spastic phase of pertussis on bronchopulmonary complications.
Summary:
- Erythromycin demonstrated superior therapeutic activity and fewer side effects compared to ampicillin in infants under one year old during the initial two weeks of pertussis.
- Antibiotic use during the spastic period of pertussis did not prevent secondary bacterial complications; instead, prophylactic antibiotic use led to a 2.6-fold increase in complications, including hospital-acquired pneumonia.
Impact:
- Antibiotic selection for pertussis should prioritize efficacy and safety, with erythromycin being a preferred choice in early stages.
- Current evidence suggests against the prophylactic use of antibiotics in later stages of pertussis to prevent secondary bacterial infections, as it may be counterproductive.
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