Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biphasic changes (initial increase and late decrease) in coronary sinus venous oxygen saturation during anginal

K Miwa1, M Fujita, M Ejiri

  • 1Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.

Cardiology
|January 1, 1992
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nanoliposomal irinotecan with fluorouracil and folinic acid in patients with unresectable or recurrent pancreatic cancer: a multicenter observational study (NAPOLEON-2).

ESMO gastrointestinal oncology·2026
Same author

Precise Measurement of Differential Cross Sections of the Σ^{-}p→Λn Reaction in Momentum Range 470-650  MeV/c.

Physical review letters·2022
Same author

Observation of Coulomb-Assisted Nuclear Bound State of Ξ^{-}-^{14}N System.

Physical review letters·2021
Same author

SAPPHIRE: a randomised phase II study of planned discontinuation or continuous treatment of oxaliplatin after six cycles of modified FOLFOX6 plus panitumumab in patients with colorectal cancer.

European journal of cancer (Oxford, England : 1990)·2019
Same author

First Determination of the Level Structure of an sd-Shell Hypernucleus, _{Λ}^{19}F.

Physical review letters·2018
Same author

Interleukin-6, interleukin-6 receptor gene variant, small-vessel disease and incident dementia.

European journal of neurology·2016

Acetylcholine dilates coronary resistance vessels in healthy individuals, increasing blood flow. In variant angina patients, it causes temporary dilation followed by dangerous epicardial artery spasm and reduced blood flow.

Area of Science:

  • Cardiology
  • Vascular Physiology

Background:

  • Coronary artery disease, particularly variant angina, involves dynamic changes in coronary blood flow.
  • Acetylcholine is a pharmacological agent used to assess coronary vascular function.

Purpose of the Study:

  • To investigate the differential effects of intracoronary acetylcholine on coronary resistance vessels in patients with variant angina versus control subjects.
  • To compare dynamic changes in coronary sinus oxygen saturation following acetylcholine administration.

Main Methods:

  • Continuous measurement of coronary sinus venous oxygen saturation using fiberoptic reflection oximetry.
  • Intracoronary injection of acetylcholine (20 micrograms) into the left coronary artery over 30 seconds.
  • Comparison between 6 control subjects and 10 patients with variant angina and left anterior descending artery spasm.

Related Experiment Videos

Main Results:

  • In controls, acetylcholine increased coronary sinus oxygen saturation, indicating increased blood flow via resistance vessel dilation.
  • In variant angina patients, acetylcholine initially increased saturation but then caused a significant decrease, associated with chest pain and ECG changes.
  • Coronary arteriography confirmed severe spasm of the left anterior descending artery in variant angina patients during acetylcholine infusion.
  • The initial increase in oxygen saturation was similar between groups, but the subsequent decrease was unique to variant angina patients.

Conclusions:

  • Acetylcholine induces vasodilation in coronary resistance vessels in healthy individuals.
  • In variant angina, acetylcholine can paradoxically trigger epicardial artery spasm, overriding the resistance vessel dilation and reducing coronary blood flow.
  • The ability of coronary resistance vessels to relax in response to acetylcholine appears preserved in patients with variant angina.