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Related Experiment Videos

The experimental Seoul-type keratoprosthesis.

H C Kim1

  • 1Department of Ophthalmology, College of Medicine, Hallym University, Seoul, Korea.

Korean Journal of Ophthalmology : KJO
|December 1, 1992
PubMed
Summary

Preventing keratoprosthesis extrusion is key for artificial cornea transplants. This study identified optimal materials and techniques, like PMMA optics and specific retention plates, to maximize device longevity in animal models.

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Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Extrusion of keratoprosthesis remains a significant challenge in artificial cornea transplantation.
  • Understanding the factors influencing device retention is crucial for improving patient outcomes.

Purpose of the Study:

  • To identify optimal conditions for maximizing the longevity of experimental keratoprosthesis through animal studies.
  • To evaluate various materials and structural designs for artificial cornea implants.

Main Methods:

  • Animal experimentation utilizing experimental keratoprosthesis of diverse materials and structures.
  • Assessment of silicone barriers for retroprosthetic membrane prevention.
  • Evaluation of fluorosilicone as an optical material.
  • Analysis of factors including optic material (PMMA), retention plate material (PTFE) and thickness, optic orientation, optic size, and suturing technique (intralamellar).

Main Results:

  • Silicone barriers were ineffective in preventing retroprosthetic membrane formation.
  • Fluorosilicone proved inadequate as an optical material.
  • Optimal conditions for keratoprosthesis retention include: PMMA optic, 0.6 mm thick PTFE retention plate, anterior optic direction, large optic size, and intralamellar suture technique.
  • Enzymatic theory is proposed as a more fitting explanation for keratoprosthesis extrusion than aseptic necrosis theory.

Conclusions:

  • Specific material choices (PMMA optic, PTFE retention plate) and surgical techniques (intralamellar suture) are critical for long-term keratoprosthesis stability.
  • Further research into the mechanisms of extrusion, potentially involving enzymatic processes, is warranted.

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