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Related Experiment Videos

[Roxithromycin in dental infections].

G Pappalardo1, B Rossetti, S Alessandra

  • 1Istituto di Clinica Odontoiatrica II, Università degli Studi di Catania.

Minerva Stomatologica
|December 1, 1992
PubMed
Summary

Roxithromycin effectively treats dental infections. This antibiotic demonstrated significant symptom improvement in patients with odontogenic infections within six days, with no reported side effects.

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Area of Science:

  • Pharmacology
  • Microbiology
  • Dentistry

Context:

  • Odontogenic infections are common oral cavity infections.
  • Roxithromycin is a macrolide antibiotic with a broad spectrum.
  • Effective treatment of dental infections requires good tissue penetration.

Purpose:

  • To evaluate the clinical efficacy and tolerance of roxithromycin in treating odontogenic infections.
  • To assess the microbiological and clinical aspects of roxithromycin treatment.
  • To determine the effectiveness of 300 mg daily dosage of roxithromycin.

Summary:

  • An open study assessed 30 patients with odontogenic infections treated with 300 mg of roxithromycin daily for 6 days.
  • Significant improvement in symptoms like swelling, redness, pain, and trismus was observed (p < 0.01).

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  • Roxithromycin showed excellent tolerance with no adverse effects or laboratory parameter changes.

    • Impact:

    • Roxithromycin is a well-tolerated and effective antibiotic for odontogenic infections.
    • The drug's pharmacokinetic profile and tissue penetration are beneficial for treating oral infections.
    • This study supports roxithromycin as a viable therapeutic option for dental bacterial infections.