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Lupus pernio.

D G James1

  • 1Royal Free Hospital, London, UK.

Lupus
|May 1, 1992
PubMed
Summary
This summary is machine-generated.

Lupus pernio, a manifestation of sarcoidosis, predominantly affects women and presents with chronic skin lesions. This study details its natural history, associated symptoms, and distinguishes it from other lupus forms.

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Area of Science:

  • Dermatology
  • Pulmonology
  • Rheumatology

Background:

  • Lupus pernio is a chronic, violaceous skin condition.
  • It is a clinical manifestation of sarcoidosis.
  • Understanding its natural history is crucial for patient management.

Purpose of the Study:

  • To describe the natural history of lupus pernio.
  • To identify associated clinical and radiological features.
  • To differentiate lupus pernio from other lupus forms.

Main Methods:

  • Observational study of 35 patients with lupus pernio.
  • Analysis of clinical, histological, and radiological data.
  • Comparison with lupus vulgaris and lupus erythematosus.

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Main Results:

  • Lupus pernio predominantly affects women, particularly those of West Indian descent.
  • Common sites include the face and digits, with lesions ranging from nodules to plaques.
  • High rates of systemic involvement observed: 74% intrathoracic, 54% upper respiratory, 54% reticulo-endothelial, 43% bone cysts, 37% ocular.

Conclusions:

  • Lupus pernio is a distinct clinical entity within sarcoidosis.
  • It exhibits characteristic facial and digital lesions with frequent systemic involvement.
  • Clinical, histological, and radiological features differentiate it from lupus vulgaris and lupus erythematosus.