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Serum osteocalcin in normal menstrual cycle
J M López Moreno1, G González, C Campino
1Departamento de Endocrinología, Metabolismo y Nutrición, Facultad de Medicina, P. Universidad Católica de Chile, Santiago.
Medicina
|January 1, 1992
Summary
Serum osteocalcin (OC) levels remained stable throughout the ovulatory menstrual cycle in healthy women. This indicates that OC is not influenced by typical hormonal fluctuations during the cycle.
Area of Science:
- Endocrinology
- Reproductive Biology
- Bone Metabolism
Background:
- Osteocalcin (OC) is a bone-specific protein involved in bone mineralization and turnover.
- Gonadotropins and ovarian steroids are known to fluctuate significantly during the menstrual cycle.
- The relationship between serum OC levels and the dynamic hormonal changes of the menstrual cycle requires clarification.
Purpose of the Study:
- To investigate the serial changes in serum osteocalcin (OC) concentrations during the ovulatory menstrual cycle.
- To determine if serum OC levels correlate with fluctuations in follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P).
Main Methods:
- Serial blood sampling was conducted every 2-3 days from day 4-5 of the cycle in 4 healthy women.
- Serum OC, FSH, LH, E2, and P levels were measured using radioimmunoassay (RIA).
- Daily ultrasound assessments were performed to monitor ovulation between days 7-18.
Main Results:
- Serum concentrations of FSH, LH, E2, and P exhibited expected cyclical variations.
- Serum osteocalcin (OC) levels remained stable and consistent within each individual throughout the entire menstrual cycle.
- No correlation was observed between serum OC concentrations and the cyclical changes in gonadotropins or ovarian steroids.
Conclusions:
- Serum osteocalcin (OC) levels are independent of gonadotropin and ovarian steroid variations during a normal ovulatory menstrual cycle.
- These findings suggest that hormonal fluctuations of the menstrual cycle do not significantly impact circulating osteocalcin levels in healthy women.