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Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
Published on: February 6, 2012
[Lead concentrations in urine correlated with cytogenetic damages in workers exposed to lead]
1Second Hospital of Changchun.
Abstract:
The lead concentrations in urine and the frequency of chromosomal aberrations and sister chromatid exchanges in lymphocytes of 84 printers exposed to lead were investigated. The results demonstrated that the lead concentrations in urine of printers were higher than normal subjects. The frequency of chromosomal aberrations and sister chromatid exchanges increased significantly with the rise of lead concentrations in urine, showing a linear correlation. The regression equations were Y = 1.31 + 9.07 X and Y = 4.24 + 14.91 X respectively. Therefore, the genetic condition of workers who have high lead concentrations in urine should be attended to and appropriate protective measures should be under-taken.

