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Colloidal bismuth subcitrate in non-ulcer dyspepsia
M U Khanna1, P Abraham, N G Nair
1Dept of Gastroenterology, KEM Hospital, Parel, Bombay, Maharashtra.
Journal of Postgraduate Medicine
|July 1, 1992
Summary
Colloidal bismuth subcitrate effectively treats non-ulcer dyspepsia symptoms and clears Helicobacter pylori infection. While symptom relief occurred in most patients, histological improvements did not correlate with symptom resolution.
Area of Science:
- Gastroenterology
- Microbiology
Background:
- Non-ulcer dyspepsia presents with diverse symptoms like pain and bloating.
- Helicobacter pylori infection is frequently associated with dyspeptic symptoms.
- Histological changes such as gastritis and duodenitis are common in these patients.
Purpose of the Study:
- To evaluate the efficacy of colloidal bismuth subcitrate (De-Nol) in managing non-ulcer dyspepsia.
- To assess the impact of colloidal bismuth subcitrate on Helicobacter pylori eradication.
- To determine the effect on histological features of the upper gastrointestinal tract.
Main Methods:
- A study involving 35 patients diagnosed with non-ulcer dyspepsia.
- Treatment administered was colloidal bismuth subcitrate (De-Nol).
- Assessment included symptom evaluation, H. pylori status testing, and histological analysis of biopsies.
Main Results:
- 82.8% of patients experienced symptom relief.
- Over 70% of H. pylori positive patients cleared the infection.
- Histological improvements in gastritis and duodenitis were observed in over 58% of cases, independent of symptom relief.
Conclusions:
- Colloidal bismuth subcitrate demonstrates short-term effectiveness for non-ulcer dyspepsia.
- The treatment contributes to H. pylori eradication and improves gastric and duodenal histology.
- Symptom improvement and histological changes were not directly correlated in this study.