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Changes in thyroid hormones in surgical trauma.

Arunabh1, A K Sarda, M G Karmarkar

  • 1Dept of Surgery, All India Institute of Medical Science, New Delhi.

Journal of Postgraduate Medicine
|July 1, 1992
PubMed
Summary

Surgical trauma alters thyroid hormone levels. Post-surgery, triiodothyronine (T3) decreased while reverse triiodothyronine (rT3) increased, indicating a shift in hormone conversion to counteract cortisol

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Area of Science:

  • Endocrinology
  • Surgical Physiology
  • Metabolic Response to Trauma

Background:

  • Surgical trauma triggers a complex physiological response, including metabolic and hormonal changes.
  • Cortisol hypersecretion during trauma induces a hypermetabolic state.

Purpose of the Study:

  • To investigate the impact of surgical trauma on circulating thyroid hormone levels.
  • To understand the peripheral conversion of thyroid hormones in response to surgical stress.

Main Methods:

  • Prospective study design.
  • Involved 20 patients undergoing elective surgery.
  • Monitored serum levels of thyroid hormones (T4, T3, rT3) pre- and post-operatively.

Main Results:

  • Serum thyroxine (T4) levels showed no significant increase post-surgery.
  • Serum triiodothyronine (T3) levels decreased following surgery.
  • Serum reverse triiodothyronine (rT3) levels increased in the post-operative period.

Conclusions:

  • Surgical trauma activates an alternative pathway for peripheral conversion of T4 to T3.
  • The observed alterations in thyroid hormone levels represent an adaptive response to trauma.
  • This hormonal shift may help counteract the effects of trauma-induced cortisol hypersecretion.

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