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Routine immunisation against chickenpox. Is it time?

C Y Hong¹, L G Goh

¹Department of Community, Occupational and Family Medicine, National University of Singapore.

The Journal of the Singapore Paediatric Society

|January 1, 1992

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The live attenuated varicella vaccine (Oka strain) offers safe and effective chickenpox prevention for children and adults. It provides protection even after exposure and is recommended for at-risk individuals.

Area of Science:

Immunology
Vaccinology
Pediatrics

Background:

Natural varicella (chickenpox) can cause inconvenient absences from school or work.
Preventing chickenpox is desirable for public health and individual well-being.

Purpose of the Study:

To evaluate the safety and efficacy of the live attenuated varicella vaccine (Oka strain).
To assess the vaccine's utility in both healthy and immunocompromised populations.

Main Methods:

The Oka strain live attenuated varicella vaccine was developed in 1974.
The vaccine was administered to leukaemic children, children with malignancies, healthy children, and adults.
Immunogenicity, safety, and protective efficacy were assessed.

Main Results:

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The varicella vaccine is safe and effective in leukaemic children, even during anticancer therapy.
In healthy children and adults, the vaccine is safe, immunogenic, and confers protection up to 10 years.
Protection can be achieved even when the vaccine is given within 3 days of exposure.
The incidence of zoster (shingles) is comparable to natural infection.

Conclusions:

The live attenuated varicella vaccine (Oka strain) is a safe and effective method for preventing chickenpox.
Routine vaccination is recommended for individuals at risk of varicella infection.
Dosage varies: one dose for healthy children, two for immunocompromised individuals and adults.