[Chromosomal analysis of human squamous cell carcinoma of the larynx]

Twenty cases of human squamous cell carcinomas of larynx were processed with an improved direct chromosome preparations. Metaphases were obtained from 5 cases and detailed G-banding analyses were completed in 3 cases. In addition, a cell line of squamous cell carcinomas of larynx (HEP-2) was analyzed with high resolution banding technique. Three generations were cytogenetically analyzed (365, 375, 395). DM, which indicate gene amplification was found in case 4 and the cell line. 6q- and i (8q) appeared in both primary tumors and the cell line, and thus could be considered as characteristic changes in human squamous cell carcinomas of larynx.