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[Antioxidant agents--importance in neonatology]
B Królak1, K Kamiński, K Olech-Jedlikowska
1Katedry i Kliniki Połoznictwa i Rozrodczości, Zabrzu.
Insights
Oxygen therapy can cause neonatal diseases like retrolental fibroplasia and bronchopulmonary dysplasia due to free radical formation. Premature infants are more susceptible, leading to "oxygen radical diseases of prematurity".
Area of Science:
- Neonatal Medicine
- Toxicology
- Biochemistry
Context:
- Oxygen therapy is crucial for neonates but carries risks.
- Neonatal diseases such as retrolental fibroplasia and bronchopulmonary dysplasia are linked to oxygen exposure.
- Premature infants exhibit increased susceptibility to oxygen's toxic effects.
Purpose:
- To explore the role of oxygen-induced free radicals in neonatal diseases.
- To investigate the heightened susceptibility of preterm infants to oxygen toxicity.
- To propose the term "oxygen radical diseases of prematurity".
Summary:
- Oxygen therapy can induce cell toxicity through the generation of reactive free radicals.
- The increased incidence of these disorders in preterm infants suggests prematurity exacerbates susceptibility.
- The hypothesis posits that antioxidant defense mechanisms in neonates are critical in mitigating these effects.
Impact:
- Understanding the etiology of "oxygen radical diseases of prematurity" is essential.
- Identifying agents that bolster antioxidant defenses may minimize oxygen therapy toxicity.
- This research could lead to improved management strategies for preterm infants receiving oxygen.
Abstract:
The toxic consequences of oxygen therapy may be development some neonatal diseases, for example: retrolental fibroplasia and bronchopulmonary dysplasia. It's now generally believed that oxygen induced cell toxicity is the result of formation of highly reactive free radicals. The greater incidence of these disorders in preterm infants suggest that some aspect of prematurity increases susceptibility of effects of toxic oxygen species. It's proposed the term for these disorders: "oxygen radical diseases of prematurity". Verification of the hypothesis about role of the antioxidant defense mechanisms of neonate may have important implications in the pursuit of the etiology these diseases and in identification of agents that may minimize toxicity associated with oxygen therapy.