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[Effect of antibiotics on the absorption of basic nutrients]
Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
|December 1, 1992
Summary
Certain antibiotics, including tetracycline, gentamicin, and streptomycin, significantly impair small intestine absorption of fats, proteins, and carbohydrates in chronic bronchitis patients. Intestinal dysbacteriosis may influence these effects.
Area of Science:
- Gastroenterology
- Pharmacology
- Microbiology
Context:
- Investigated the effects of common antibiotics on gastrointestinal absorption in patients with chronic bronchitis.
- Assessed the impact of tetracycline, gentamicin, streptomycin, erythromycin, oxacillin, benzylpenicillin, and sulfanilamides.
- Included 79 patients diagnosed with chronic bronchitis.
Purpose:
- To evaluate the influence of various antibiotics on the absorptive function of the small intestine.
- To determine the extent to which these drugs affect the absorption of fats, proteins, and carbohydrates.
- To explore the relationship between antibiotic-induced changes in absorption and intestinal dysbacteriosis.
Summary:
- Antibiotics like tetracycline, gentamicin, and streptomycin markedly reduced fat absorption (87%, 89%, 36% respectively) and protein absorption (23-74%).
- Carbohydrate absorption (d-xylose) was also significantly decreased by tetracycline, gentamicin, and streptomycin (21-36%).
- Erythromycin and oxacillin showed milder effects on fat absorption, with minimal impact on protein and carbohydrate absorption.
Impact:
- Highlights potential gastrointestinal side effects of commonly prescribed antibiotics in chronic bronchitis patients.
- Suggests that antibiotic choice and duration may need consideration to mitigate malabsorption.
- Underscores the link between antibiotic use, intestinal dysbacteriosis, and impaired nutrient absorption.