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Related Experiment Videos

Altered plasma lipid pattern in falciparum malaria.

S Mohanty1, S K Mishra, B S Das

  • 1Ispat General Hospital, Orissa, India.

Annals of Tropical Medicine and Parasitology
|December 1, 1992
PubMed
Summary

Malaria significantly alters plasma lipid profiles, increasing total cholesterol and decreasing triglycerides. These changes, particularly in severe falciparum malaria, can mislead atherosclerosis risk assessments immediately post-infection.

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Area of Science:

  • Biochemistry
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Falciparum malaria is a significant global health concern.
  • Plasma lipid profiles are crucial indicators of cardiovascular health.
  • Malaria's impact on lipid metabolism requires further investigation.

Purpose of the Study:

  • To investigate malaria-induced alterations in plasma lipid levels.
  • To compare lipid profiles between malaria patients (mild and severe) and healthy controls.
  • To assess the implications of these changes for atherosclerosis risk evaluation.

Main Methods:

  • Plasma levels of HDL, LDL, total cholesterol, and triglycerides were measured.
  • Lipid levels were compared between 60 malaria patients and 83 healthy individuals.

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  • Nephelometry was used to estimate lipoprotein levels, overcoming limitations of the Friedewald formula.

    • Main Results:

    • Severe malaria cases showed significantly lower triglycerides and higher total cholesterol, HDL, and LDL compared to mild cases and controls.
    • Lipoprotein S particles (LDL) were lower in all malaria cases.
    • Elevated L particles in severe malaria indicated impaired chylomicron metabolism.
    • Reduced albumin levels correlated with HDL cholesterol.

    Conclusions:

    • Falciparum malaria induces significant, complex changes in plasma lipid profiles.
    • Elevated total cholesterol post-malaria can be misleading for atherosclerosis risk assessment.
    • Impaired chylomicron metabolism and altered lipoprotein levels are key findings in severe malaria.