Studies concerning the effect of Ukrain in vivo and in vitro

Ukrain, a reaction product of different alkaloids of Chelidonium majus L. (celandine) with Thio tepa has been investigated for possible use as an anticancer agent. A possible tumour inhibiting effect on the Ehrlich mouse ascites tumour is now tested in vivo. Moreover, possible changes in the oxygen consumption of mouse ascites tumour cells and a guinea pig liver homogenate are to be determined after the administration of Ukrain in vitro with the aid of an oxygen electrode.