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[The use of hypoxic stimulation in chronic and relapsing bronchitis in young children ]
Insights
Pediatric bronchitis is linked to reduced cellular immunity and increased oxidative stress. Normobaric hypoxic stimulation may be crucial for treating and preventing childhood bronchitis.
Area of Science:
- Pediatric immunology
- Biochemistry
- Respiratory medicine
Background:
- Bronchitis in children presents with complex immunological and biochemical changes.
- Hypoxic states are observed in children with various forms of bronchitis.
Purpose of the Study:
- To examine immunological and biochemical markers in children with bronchitis.
- To investigate the role of oxidative stress and cellular immunity in pediatric bronchitis.
- To evaluate the effectiveness of treatment on metabolic disorders.
Main Methods:
- Immunological examination including E-rosette forming cells (E-RFC) and phytohemagglutinin-induced blast transformation.
- Biochemical analysis measuring malonic dialdehyde concentration.
- Assessment of erythrocyte membrane resistance to peroxide hemolysis.
Main Results:
- Children with bronchitis showed decreased cellular immunity indices (E-RFC, blast transformation) and dysgammaglobulinemia.
- Increased malonic dialdehyde and erythrocyte membrane resistance to peroxide hemolysis during exacerbations.
- Treatment improved clinical symptoms but did not normalize metabolic disorders related to peroxidation.
Conclusions:
- Pediatric bronchitis is associated with significant immune dysregulation and oxidative stress.
- Metabolic disturbances persist post-treatment, suggesting a need for targeted interventions.
- Normobaric hypoxic stimulation is proposed as a therapeutic and preventive strategy for childhood bronchitis.
Abstract:
214 children of different age with various forms of bronchitis were subject to immunological and biochemical examination. Against a background of hypoxic state of patients the values of quantitative indices of cellular immunity (E-RFC, blast-transformation reaction with phytohemagglutination) were revealed to decrease and dysimmunoglobulinemia-to form. It is shown that in the period of exacerbation of clinical symptoms of bronchitis the concentration of malonic dialdehyde and resistance of erythrocyte membranes to peroxide hemolysis significantly increase. Analysis of peroxidation level against a background of improvement of clinical indices after the performed treatment indicates that there is no tendency to normalization of metabolic disorders. The above results show that it is necessary to carry out normobaric hypoxic stimulation aimed at treating and preventing bronchitis in children of early age.