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Related Experiment Videos

"Positive" and "negative" movement disorders in schizophrenia.

R Sandyk1, S R Kay

  • 1Department of Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York 10461.

The International Journal of Neuroscience
|October 1, 1992
PubMed
Summary

Tardive dyskinesia (TD) in schizophrenia correlates with positive symptoms, while drug-induced parkinsonism (DIP) links to negative symptoms. This suggests TD is a "positive" and DIP a "negative" movement disorder in schizophrenia patients.

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Clinical characteristics differentiating tardive dyskinesia (TD) from non-TD patients remain unclear.
  • Previous research suggests TD in schizophrenia may correlate with positive symptoms, and drug-induced parkinsonism (DIP) with negative symptoms.

Purpose of the Study:

  • To investigate the relationship between TD and DIP with specific psychopathology clusters in schizophrenic patients.
  • To test the hypothesis that TD is associated with positive symptoms and DIP with negative symptoms.

Main Methods:

  • Examined 47 institutionalized schizophrenic patients.
  • Assessed TD and DIP using psychopathology clusters from the Positive and Negative Syndrome Scale.

Main Results:

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  • TD involuntary movements significantly correlated with the activation cluster (p < .01).
  • DIP significantly correlated with the anergia cluster (p < .01).

Conclusions:

  • Findings support TD as a facet of the positive syndrome and DIP as a feature of the negative syndrome in schizophrenia.
  • Schizophrenic patients with positive symptoms may have higher TD risk; those with negative symptoms may have higher DIP risk.
  • Proposes TD as a "positive" and DIP as a "negative" movement disorder.