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Related Experiment Videos

Ice cube test in children with cold urticaria.

N Visitsuntorn1, M Tuchinda, N Arunyanark

  • 1Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Asian Pacific Journal of Allergy and Immunology
|December 1, 1992
PubMed
Summary

The ice cube test is effective for diagnosing cold urticaria in children when applied for 3-5 minutes. Prolonged testing may yield false positives, but extended durations are useful after antihistamine therapy.

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Area of Science:

  • Pediatric Dermatology
  • Allergology
  • Immunology

Background:

  • Cold urticaria is a physical urticaria triggered by cold exposure.
  • Accurate diagnosis in children is crucial for effective management.
  • The optimal duration of the ice cube test for diagnosing cold urticaria in pediatric patients requires clarification.

Purpose of the Study:

  • To determine the appropriate duration of the ice cube test for diagnosing cold urticaria in children.
  • To evaluate the occurrence of false positive results with prolonged ice cube test durations.
  • To assess the impact of antihistamine therapy on the diagnostic utility of the ice cube test.

Main Methods:

  • The ice cube test was administered to 24 children, including those with cold urticaria, healthy controls, allergic conditions, and chronic urticaria.

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  • Testing durations included 3, 5, 10, and 20 minutes.
  • The ice cube test was repeated after four weeks of cyproheptadine therapy in some patients.

    • Main Results:

    • A 3-5 minute ice cube test accurately diagnosed cold urticaria without false positives.
    • Prolonging the test to 10 or 20 minutes resulted in 17% and 33% false positives in non-cold urticaria patients, respectively.
    • After cyproheptadine therapy, 3-5 minute tests showed 17-33% positivity, while 10-20 minute tests showed 67% positivity.

    Conclusions:

    • The standard ice cube test duration for diagnosing pediatric cold urticaria should be 3-5 minutes.
    • Extended test durations (10-20 minutes) may be necessary for diagnosis after antihistamine treatment if initial tests are negative.