[Genetic polymorphism of complement component six (C6) in five Han subpopulations]

J Hu1, R Du

  • 1Institute of Genetics, Chinese Academy of Sciences, Beijing.

Yi Chuan Xue Bao = Acta Genetica Sinica
|January 1, 1992
PubMed

By using polyacrylamide gel isoelectric focusing followed by immunoassay, the polymorphism of Complement Component Six (C6) was investigated in five Han subpopulations in China. The following gene frequencies were obtained Zhengzhou Han: C6*A 0.4521, C6*B 0.5228, C 6*B2 0.0183, C6*R 0.0068; Lanzhou Han: C6*A 0.4612, C6*B 0.5218, C6*B2 0.0170; Huhhot Han: C6*A 0.4452, C6*B 0.5286, C6*B2 0.0214, C6*R 0.0048; Xi'an Han: C6*A 0.4899, C6*B 0.4874, C6*B2 0.0126, C6*R 0.0101; Hakka of Meizhou, Guangdong Province: C6*A 0.4569, C6*B 0.5152, C6*B 0.0279 (C6*R is the frequency of rare alleles).

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
What is Population Genetics?01:25

What is Population Genetics?

A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.While some alleles of a given gene might be observed commonly, other variants...
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Complementation Tests00:49

Complementation Tests

A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...