Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cell-matrix interactions and odontoblast differentiation].

H Lesot1, C Begue-Kirn, A J Smith

  • 1Institut de Biologie Médicale, INSERM CJF 88-08, Faculté de Médecine, Strasbourg.

Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topical sucralfate in the management of peristomal skin disease: an open study.

Clinical and experimental dermatology·2001
Same author

Development and evaluation of a stand-alone web-based CAL program. A case study.

European journal of dental education : official journal of the Association for Dental Education in Europe·2001
Same author

The bio-availability of fluoride from black tea.

Journal of dentistry·2001
Same author

Quality use of medicines in the community: the Australian experience.

British journal of clinical pharmacology·2001
Same author

Genomic organization and comparative analysis of the mouse tuberous sclerosis 1 (Tsc1) locus.

Mammalian genome : official journal of the International Mammalian Genome Society·2000
Same author

The spectrum of skin disorders in abdominal stoma patients.

The British journal of dermatology·2000

Odontoblast differentiation depends on cell-matrix interactions involving growth factors and matrix molecules. Understanding these interactions is key to modulating cell phenotype in dental development.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Biochemistry

Context:

  • Odontoblast terminal differentiation is crucial for dentin formation.
  • Cell-matrix interactions and growth factors regulate this process.
  • The cytoskeleton's integrity is essential for odontoblast differentiation.

Purpose:

  • To elucidate the role of cell-matrix interactions in odontoblast differentiation.
  • To identify specific matrix molecules and growth factors involved.
  • To explore the mechanisms by which these factors influence odontoblast phenotype.

Summary:

  • Predentin-dentin constituents and transforming growth factor-beta (TGF-β) initiate and maintain odontoblast differentiation.
  • Fibronectin induces differentiation of secondary odontoblasts by interacting with cell surface proteins.

Related Experiment Videos

  • A 165 kDa protein on odontoblast surfaces is involved in microfilament organization.

    • Impact:

    • Provides insights into the molecular mechanisms of dentinogenesis.
    • Highlights the importance of cell-matrix signaling in tooth development.
    • Suggests future research directions for understanding cell-matrix modulation in dental tissues.